The Leopards will be on the US 71 for the second week in a row, this time heading south instead of north. De Queen will face Ashdown at 7:30 Friday.
The Panthers are coming off a 30-20 loss to Hamburg. "They have a very good defense overall," said De Queen head coach Stephen Sloan.
"They have a great front four, two big physical linebackers and four guys in the secondary who can flat out run."
Offensively, the Panthers have some similarity with the Leopards. "They're starting a sophomore quarterback," said Sloan. "They are trying to get their running game going to set up passes. They have a lot of speed on offense too."